N-Coumaroyldopamine

1. What Is It?

N-Coumaroyldopamine is a naturally occurring compound, commonly found in various plants including cocoa (also known as Theobroma cacao L.). The compound of N-Coumaroyldopamine can be both sourced naturally, as we just mentioned, but it can also be synthetically made and used in products. Typically you will see the nutritional panel refer to ‘Cocoa Seed Extract’ which should then ‘standardised to x% of N-Coumaroyldopamine’. N-Coumaroyldopamine is referred to as a beta-2 agonist, which is the main function for which it is used in the supplements we find it in.

2. What Does It Do?

As we just mentioned above, N-Coumaroyldopamine is a beta-2 agonist, or to be more precise, a beta-2 adrenoreceptor agonist. What do we mean by ‘agonist’? N-Coumaroyldopamine has the ability to ‘turn on’ the beta-2 adrenoreceptors in the body. There are plenty of synthetic beta-2 agonists such as salbutamol, procaterol, fenoterol, also clenbuterol. N-Coumaroyldopamine being naturally sourced from cocoa seed extract makes it very attractive as a natural alternative that could yield similar results to the more ‘hardcore’ synthetics. Beta-2 Adrenoreceptors play a number of roles in the body which we will get into now.

Increase Levels of cAMP

One of the key chemical messengers in the body is Cyclic Adenosine Monophosphate (also known as cAMP). Think of cAMP as a manager of signals in the body; the receptor sends the signal to cAMP and it then passes on the relevant information to make the bodily functions occur. cAMP plays a role in an endless list of functions the body such as regulating thermogenesis, inducing lipolysis and the oxidation of fatty acids, vasodilation, and even nutrient uptake and oxygen delivery to skeletal muscles. N-Coumaroyldopamine has been studied and shown to increase cAMP levels in the body through the Beta-2 Adrenoreceptors.

Increased Metabolic Rate & Lipolysis

Through this increased release of cAMP from the turning on of beta-2 adrenoreceptors by N-Coumaroyldopamine we have some very desirable effects occurring. For fat loss, the increase in not only the metabolic rate but the RESTING metabolic rate and caloric expenditure is hugely beneficial. Throw in the increased breakdown of fats through lipolysis, and the increased burning of fatty acids and we have really ramped up the bodies natural fat loss process. Being able to not only increase the number of calories being burnt but also ensure we are breaking down stored fat to be used in this increased caloric expenditure is hugely beneficial.

Increased Bloodflow

Beta-2 adrenoreceptors, the receptors turned on by N-Coumaroyldopamine, have been shown to induce dilation in the vascular system of the body. By ‘induce dilation’ we are referring to increasing the process of vasodilation, or the relaxing & widening of blood vessels. This vasodilation hosts a number of benefits that aids in physical performance, fat loss and muscle growth. Increased nutrient delivery to muscle cells is a huge benefit of increased vasodilation, the more nutrients we get delivered to the muscle cell the better and faster we can recover and be able to perform again at a higher level. As well as this, increased oxygen delivery is another massive benefit of vasodilation. Being able to increase the rate of oxygen being delivered to the working muscles and around the body is unbelievable crucial and beneficial for all elements of performance and recovery, let alone, day to day life.

Reduced Muscle Protein Usage (Catabolism)

N-Coumaroyldopamine has also been shown to have an anabolic effect in muscle tissue through the Beta-2 adrenoreceptor pathway. These receptors have been shown to have a positive effect on patients suffering from muscle wasting diseases such as sarcopenia and cachexia. The entire process isn’t fully understood but N-Coumaroyldopamine’s effect on Beta-2 Adrenoreceptors has been shown to reduce gluconeogenesis, which is the breakdown of non-carbohydrate stores to create glucose. This reduced chance of proteins being broken down to create glucose could tie into the muscle-sparing effect of N-Coumaroyldopamine supplementation.

3. How Much Do I Need To Take?

While there is no scientifically proven / recognised dose. Typical we are seeing a dose of between 20 - 40 mg of N-Coumaroyldopamine per day, every day. While this ingredient is being used in a variety of different types of supplements in the market, you will sometimes see the dose broken down into smaller doses designed to be taken multiple times per day. Alternatively, larger doses of 40 mg have been seen in once a day style products.

4. When Do I Take It?

The benefits of supplementing with N-Coumaroyldopamine aren’t instantaneous and also don’t require specific timing of consumption. Taking N-Coumaroyldopamine consistently on a daily basis is the best approach to yield the best results. Where you source your N-Coumaroyldopamine is the biggest determining factor of when and how you will consume it. Whether it be first thing in the morning in a fat burner or spaced throughout the day in a recomposition supplement, or ever taken whenever you consume your daily vitamins and minerals.

The consistent and regular consumption of N-Coumaroyldopamine is the key element to yielding the best results from its use.

5. How Long Does It Take To Work?

As we just mentioned, the benefits from N-Coumaroyldopamine are not instantaneous and therefore the consistent consumption is key to get the full benefits. On top of this, the benefits from supplementing with N-Coumaroyldopamine aren’t exactly that noticeable from day to day. If you were to keep all variables the same and simply add N-Coumaroyldopamine into your supplement regime, you would be able to notice the potential body fat loss, increased vasodilation while training. But given most users of this ingredient and products using this ingredient will be following a training or diet plan or every a contest prep plan where there are 100’s of other variables being adjusted it will be hard to pinpoint the results.

We expect, after consistent consumption of N-Coumaroyldopamine, to see the full effects of this ingredient in 2 weeks of use. Consistency is the key to yielding the full benefits possible.

6. What Are The Top Products?

The top products containing N-Coumaroyldopamine are:

Core Nutritionals Hard Extreme

'Merica Labz Uncle Bam

Sparta Nutrition Hydra Shred

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